Dental Update Malignant oral melanoma: how to spot it and how it is managed Dental Update Labial melanotic macule Mucosal melanocytic macules Table 3 from Dermoscopy of venous lake on the lips: A comparative study with labial melanotic macule Semantic Scholar Brown spots, especially on the lips, can be alarming to some. In some instances it can indicate rare oral mucosal melanoma, however in this case it was a non cancerous labial melanotic macule.