Glucose 6 Phosphate Dehydrogenase: Update and Analysis of New Mutations around the World Loss of glucose 6 phosphate dehydrogenase function increases oxidative stress and glutaminolysis in metastasizing melanoma cells PNAS Glucose 6 phosphate dehydrogenase (G6PD) deficiency X linked recessive Xq28 is not true recessive as heterozygotes can express the trait; G6PD > No NADPH > No RBC glutathione protection > free radical damage hemolysis Anemia (Chapter 3) Pediatric Pathology of Hematopoietic and Histiocytic Disorders Although G6PD deficiency, which can cause problems in red blood cells upon certain triggers, is the most common human enzyme defect, affecting over 400 million people, including over 1 in 10 Black