In patients with liver disease, acetaminophen metabolism is altered: the half life may be prolonged, and glutathione stores may be reduced, Therefore, acetaminophen can be used safely at reduced doses Glutathione supplement for fatty liver disease : Medznat Hyperhomocysteinemia in Liver Cirrhosis Hypertension Dysregulation of glutathione synthesis in liver disease ScienceDirect Glutathione: The Master Antioxidant Core Med Science