Cyanocobalamin vs Hydroxocobalamin (Vitamin B12 forms) Key Clinical Differences Hydroxocobalamin is preferred in: Pernicious anemia Severe vitamin B12 deficiency Neurological symptoms (subacute combined degeneration, neuropathy) Cyanocobalamin is Wow guys, you've been gate keeping!! Got my first B12 injection last week and it's like I am awake for the first time since having kids 20 years ago It's Are B12 Injections Safe? Should I Get A B12 Shot? Vitamin B12 shots: Uses, benefits, and side effects B12 injections have lots of benefits from just 1 dose. A dose can be given every 6 months to boost benefits, unless you have a b12 deficiency or pernicious anaemia with proof