Labial melanotic macule Melanocytic Lesions A Guide to Clinical Differential Diagnosis of Oral Mucosal Lesions Continuing Education Course dentalcare.com Malignant Melanoma the mole in the skin! HubPages Brown spots, especially on the lips, can be alarming to some. In some instances it can indicate rare oral mucosal melanoma, however in this case it was a non cancerous labial melanotic macule. COM March 2009 Diagnosis UW School of Dentistry