Tylenol's Impact on Glutathione and Liver Damage Yes there is good evidence that acetaminophen (the active ingredient in Tylenol) can deplete glutathione under certain conditions. But whether that matters depends on dose, duration, and individual factors. How can I minimize liver damage while taking Tylenol (acetaminophen) in relation to glutathione levels? Is Tylenol Safe During Pregnancy? Understanding Risk Factors Seeking Health Tylenol Glutathione Kizer Wellness LLC