Pathology Outlines Melanotic macule COM August 2004 Diagnosis UW School of Dentistry Differential Diagnosis of Pigmented Lesions in the Oral Mucosa: A Clinical Based Overview and Narrative Review Pigmented lesions of the oral mucosa and perioral : Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, & Endodontics An oral melanotic macule is a harmless dark spot found on the lip, most often the lower lip, or inside the mouth, either on the gums, inside the cheek, or on the roof of the mouth. An oral melanotic