Can I Use Glutathione With Tretinoin Tretinoin for Hyperpigmentation? Yes its a great approach Tretinoin helps speed up skin renewal, improving the look of dark spots over time. To boost results, use Glutathione + Vitamin C during What to Pair and Avoid with Glutathione Glutathione and Tretinoin Together TikTok Glutathione + Tretinoin combo for uneven skintone and hyperpigmentation different lighting : r skinwhitening