How to Give a B12 Injection: Step By Step Instructions Safe intramuscular (IM) injection in the gluteal region is given in the upper outer quadrant to avoid sciatic nerve injury. Incorrect site selection (inner, lower, or medial areas) increases the risk of Taylor demonstrates the proper technique for administering an intramuscular injection. Locate the upper, outer quadrant of the buttock muscle Prepare the site with alcohol Insert needle all the What Happens If You Inject B12 Wrong: 6 Red Flags How to perform a glute injection (intramuscular injection)